Kim Hoagland, PhD

Research Fellow, Safety and Exporatory Pharmacology

 

What are your department’s specific needs in terms of data acquisition?

"The Department of Safety and Exploratory Pharmacology at Merck is interested in software that not only offers solutions for accurately marking the ECG and blood pressure waveforms for cardiovascular (CV) work, but an application package that is capable of great flexibility to accommodate a wide variety of study designs and different analysis methods to analyze data.
For example, we conduct studies using models in 5 different species. The diversity in models, varying types of study designs and different analysis paradigms makes analysis flexibility a priority for us, as we do not analyze all sets of data in the same manner. In addition, high throughput of data to meet critical timelines is important.
The criticality of accuracy, flexibility, and speed has made us very selective in our pursuit of a software application for our CV work."

Why did you choose NOTOCORD as your primary software solution for your telemetry assays?

"As mentioned, a high priority for us is flexibility in the design of our studies. The ability to use different analysis methods to obtain data that best meet study objectives is very important. This means that we need to have the ability to change our analysis paradigms quickly and interface with various graphing and statistical applications, all of which are Excel-based or -compatible.
NOTOCORD allows for this flexibility since the extraction methods are built into Microsoft Excel® and allow the user the ability to use various types of analysis methods, including different data binning methods, data treatments (ie: data transformation) and graphing presentation methods.
Furthermore, we have found that we have been able to use features of NOTOCORD to verify marking accuracy, collect file statistics and make individual file/animal modifications, since the telemetry signals in a large telemetry file are never 100% perfect over a given time interval. We need to be able to analyze the available data to the best of our ability in such circumstances.
Lastly, we have been impressed with the customer service with NOTOCORD, which has allowed us to maximize our use of the software and get excellent solutions to meet our scientific needs."

How long have you been using NOTOCORD software?

"We have been using NOTOCORD for over a decade here at Merck for both in vitro, in situ and in vivo model work and have been pleased with the new Evolution® version, as it offers great flexibility and has increased the throughput for our CV assays. In addition, the arrhythmia detection module* newly offered by NOTOCORD is intriguing!
I have been a NOTOCORD user since 2003, after joining Quintiles preclinical Safety Pharmacology group in Kansas City, MO. We used NOTOCORD to conduct GLP and non-GLP dog and monkey telemetry work at Quintiles and made use of the VME10e module in 2005. When I joined Merck in 2007, we began to set up rodent telemetry, and after working with some other software applications decided to use NOTOCORD for rat and mouse telemetry.More recently, we have been looking for a new telemetry software package for non-rodent telemetry studies and have found ECG51a** to be applicable to our needs for these studies.
We have also pilot-tested the arrhythmia detector* and have found it to be very valuable for helping us to detect ECG morphology changes and/or changes in rhythm that may provide important risk assessment information."

What are your expectations while using NOTOCORD-hem?

"Simply put: we want to use NOTOCORD to obtain high quality data (accuracy) from both small and large animal assays, in a GLP compliant manner. It is also important that the data analysis be efficient to sup-port the high throughput nature of our business needs."

* ARR30a—Arrhythmia detector
** ECG51a—Semi-automated ECG analyzer