Analysis of respiration signals
Our portfolio includes analysis modules for respiratory signals collected from a variety of experimental setups such as plethysmography, pneumotachography, implants, catheter etc. NOTOCORD-hem™ Evolution acquisition servers are compatible with any hardware providing BNC analog outputs.
Signals acquired during plethysmography experiments are first corrected for baseline drift on a cycle-by-cycle basis before any parameter computation. Extracted respiratory parameters include instantaneous and tidal volumes, respiratory rate, inspiratory and expiratory times, peak inspiratory and expiratory flows.
Regarding acquisition, our server BUX10a automatically identifies Buxco MAXII and MAX1500 hardware connected to the computer via a USB 2.0 port. For EMMS hardware we provide a 1-12 channel demultiplexer, in accordance with the number of connected plethysmographs that continuously measures temperature and relative humidity.
Example analysis - whole body plethysmography (WBP)
Whole body plethysmography (WBP) experiments are widely used in basic and preclinical research for non-invasive pulmonary measurements of conscious and unrestrained animals. At NOTOCORD®, we developped several modules to help you deal with signal acquisition and analysis.
Our analyzers PLY30b and PLY30m both perform analysis of ventilatory parameters and compute enhanced pause parameter (PENH). PLY30b is suitable for animals with respiratory rate up to 360 breaths/minute, and uses constant user-defined values of chamber’s temperature and humidity and animal’s temperature for flow and volume estimation. PLY30m is suitable for animals with respiratory rate up to 600 breaths/minute, and offers an optional dynamic correction factor for changes in animal temperature, chamber temperature and chamber relative humidity.
Example analysis - head-out plethysmography (HOP)
For Head-Out Plethysmography (HOP) signals, our analyzer PLY30h extracts respiratory parameters and computes PENH. PLY30h is suitable for animals with respiratory rate up to 600 breaths/minute.
Extracted and computed parameters include respiratory flow and volume, inspiration and expiration times, respiration rate and relaxation time.
Pneumotacograph experiments provide continuous recording of instantaneous respiratory air flow rates, assessing respiratory mechanics in restraint animals.
RSP30a, our respiration analyzer for restraint animals, computes airway resistance and lung elastance in addition to standard ventilatory parameters such as instantaneous tidal and minute volumes, inspiratory and expiratory times, respiratory rate, resistance and compliance.
Respiratory impedance signal, as provided by DSI's D70-PCTR implant for telemetered cardiorespiratory studies on freely moving large animals, allows indirect assessment of respiratory rate, tidal volume and minute ventilation.
Our analyzer RIA30a extracts all parameters recommended by the ICH S7A for the Respiratory Core Battery from the impedance signal only.
Intra-thoracic pressure signal is commonly obtained using a catheter inside the thoracic cavity and allows indirect assessment of the respiratory system.
TPA30a, our online analyzer for intra-thoracic pressure signal, computes for each respiratory cycle the respiratory rate, depth, minimum and maximum pressures, and inspiratory and expiratory times. TPA30a is compatible with any intra-thoracic pressure catheter.
|BUX10a||Buxco MAX II / MAX 1500 Acquisition server|
|PLY30b||Whole body plethysmography respiration analyzer|
|PLY30h||Head-out plethysmography respiration analyzer|
|PLY30m||Respiration whole body plethysmography analyzer with correction (up to 600 bpm)|
|RFP10a||Respiration rate from blood pressure|
|RIA30a||Respiratory impedance analyzer|
|RSP30a||Restraint animal respiration analyzer|
|TPA30a||Intra-thoracic pressure analyzer|
|VMA10a||Inductive Plethysmography Analyzer|