NOTOCORD® welcomes you at booth #2, on the ground floor right in front of the buffet, during the 13th annual meeting of the Safety Pharmacology Society that will take place in Rotterdam (The Netherlands) on September 16-19, 2013.
We will be happy to discuss about your needs for data acquisition and analysis, present our software solutions and see how we can set up or improve your system.
Working with cardiovascular telemetry implants ?
We also plan on showing at the SPS 2013 a first version of one of our most exciting project, CardioXpress, an innovative tool designed in partnership with Multi-Channel Systems and Pluriomics to explore the potential of stem cells in pharmacology studies and consider alternatives to animal-based experimentations.
The CardioXpress project
The main objective is to provide a fast, completely expandable turnkey system to get a mechanistic view of drug activity on the cardiovascular system.
We aim to build disposable multi-well MEA (Micro Electrode Array) sensing plates with miniaturized wells for automated High Throughput Screening (HTS) assays based on highly-differentiated human stem cells-derived cardiomyocytes hPSC-CM.
hPSC-CM share many features of human adult ventricular cardiomyocytes. Records and analysis of hPSC-CM field potential responses to different concentrations of potential drugs will be saved and analyzed online / offline with advanced techniques to predict the effects on cardiac electrical activity of one or similar groups of compounds.
Our software solution
For now, data acquisition is performed with MCS apparatus while analysis and reporting to Microsoft Excel® are performed with NOTOCORD® software.
To fit the project requirements NOTOCORD® is developing a new software platform and a dedicated user-friendly and semi-automated field potential analyzer with the first version scheduled for release in early 2014.
Automated assessment of signal quality, visible to the user via a simple and efficient color code system, allows to perform analysis only on wells of interest, and to globally increase the quality of the whole assay.
In the long run, we are looking at a fast, powerful and fully integrated solution from acquisition to reporting.